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CDMI Fall 2018 Symposium

September 13-14, 2018
UC San Francisco - Mission Bay Campus
Women’s Hospital Conference Center
William and Susan Oberndorf Auditorium
This event is open to ALL MUSCULOSKELETAL industry representatives and university musculoskeletal researchers and clinicians.
Come together with researchers, clinicians, and high level executives from top orthopaedic companies to learn about the latest musculoskeletal innovations from four different campuses (UC San Francisco, University of Toledo, The Ohio State University, and Northeastern University). In this semi-annual event, the Center's Industry Advisory Board will select which projects to fund this cycle and hear updates from previously funded projects. This year's keynote will discuss cutting-edge projects using machine learning. 
Symposium Agenda

Day 1 - Thursday, September 13, 2018

Betty Irene Moore Women’s Hospital

William and Susan Oberndorf Auditorium

7:30 am 

7:30-8:00 am 

8:00-8:25 am 


8:25-8:45 am 


8:45-9:00 am



9:00-9:55 am

9:55-10:05 am

10:05-11:00 am

11:00-11:20 am

11:20-12:30 pm

12:30-12:50 pm

12:50-1:30 pm

1:30-1:40 pm

1:40-2:35 pm

2:35-2:45 pm

2:45-3:30 pm


3:40-4:45 pm

4:45-5:00 pm

5:00-6:00 pm




Welcome Remarks, Introductions & CDMI Update

Drs. Jeffrey Lotz & Vijay Goel – CDMI Site Directors

Keynote - Bringing AI to the Bedside
Rachael Callcut, MD, MSPH, Associate Professor

Department of Surgery, UC San Francisco

Introduction to Presentations

Drs. Jeffrey Lotz & Denis Gray (NSF I/UCRC Evaluator)

Research Area 1 - Clinical Outcomes

  1. Identifying Risk Factors for Pseudarthrosis

  2. Implementation of a mobile application in the treatment of chronic nonspecific low back pain

  3. Deep learning lesion mapping and expected patient outcomes from spinal radiographic imaging

  4. The Fitbit Effect in Lumbar Spine Surgery, 1 to 2 year follow-up study

  5. Development of a Total Joint Arthroplasty Registry at an Academic Tertiary Referral Center for the Study of Race and Socioeconomic-Based Outcome Disparities


BREAK (snacks provided)

Research Area 2 - Biomechanics

  1. Incorporating Active Apex Correction alongside Guided Growth Technique: Avoiding Risky -Osteotomies and the Loss of Correction in Early Onset Scoliosis

  2. Spino-pelvic Biomechanics for the Treatment of Spinal Disorders- A Finite Element Study

  3. Development of a Protocol to Evaluate Growth Rods in a Missing Vertebra Model

  4. Effect of Tapered Bone Cement Injection on the PJK in a Finite Element Model with Muscle Forces

  5. Biomechanics of Lateral Inter Spinous Spacer and Lateral Cage for Spinal Fusion


Andrew Baumann, PhD - Division of Applied Mechanics, U.S. Food and Drug Administration


NSF I/UCRC Presentation

Andre W. Marshall, PhD - NSF I/UCRC Program Director

Technology Presentations

  • Latest on Imaging and Back Pain

      Aaron Fields, PhD, Assistant Professor, Department of Orthopaedic Surgery

  • 3D printing yesterday, today, and tomorrow

      Alexis Dang, MD, Associate Professor, Department of Orthopaedic Surgery


BREAK (snacks provided)


Research Area 3 - Innovative Devices, Tools, or Assessment Techniques

  1. Pedicle Screw Handling During Surgery Contribute to Bioburden and Potential Approaches to Reduce Rate of Infection in Patients– A Multi-Center Study

  2. Static and dynamic changes in spinopelvic parameters and sagittal alignment

  3. Development of a 3D printed scaffold for restoring muscle attachment in posterior spine surgery

  4. Improved orthopedic pre-surgical planning using high-fidelity CT/MRI derived 3D Augmented Reality models

  5. Sensorized SMART Spine Brace for Assessment and Tracking of Post-surgical Recovery

BREAK (snacks provided)

Research Area 4 - Other Topics

  1. Magnetic Injectable Self-Setting Calcium Phosphate Cement (CPC) Compositions for Hyperthermia Treatment of Bone Tumors

  2. Insights into Cartilage Tissue Property Changes in Osteoarthritis through Advanced Glycation End-Products

  3. Feasibility and Biocompatibility of SLA 3D printed, nano beta-TCP scaffolds

  4. Low-intensity Pulsed Ultrasound as a Novel Therapy for Disc Repair and Reduction of Disc Degeneration

BREAK (snacks provided)

Final 2017-2018 Project Presentations: UC San Francisco

  1. High-throughput screening for osteocyte-mediated bone remodeling (OMBRE) regulatory compounds

  2. Nerve/Bone Crosstalk: PEMF control of cAMP-sensitive TGFb signaling

  3. Predictive modeling for clinical outcomes and cost-effectiveness of surgery for lumbar degenerative pathologies and spinal deformity

  4. Mechanisms of post-discectomy vertebral endplate changes

  5. Animal Model to Characterize Natural History of Intracept Basivertebral Nerve Ablation

Review of Day 2 Activities and CDMI Organizational Meeting/Formative Discussion

Drs. Jeffrey Lotz & Denis Gray

RECEPTION (hors d’oeuvres + drinks)

Day 2
Day 2 - Friday, September 14, 2018

Mission Hall

Global Health and Clinical  Sciences Building, Room 2103

7:00-7:30 am 

7:30-9:00 am 

9:00-9:10 am 

9:10-10:30 am 

10:30-10:40 am

10:40-11:00 am

11:00-11:40 am





11:40-12:45 pm

11:55-12:35 pm






NETWORKING (breakfast provided)

LIFE FORM Review and Discussion of  2018-19 Projects with Faculty

BREAK (snacks provided)

IAB Meeting – Voting Session

(Closed Door - IAB Members and NSF only)

BREAK (snacks provided)


Discussion Session

  - IAB Report Out

  - Updates from The Ohio State University and Northeastern University

  - Action Items

  - Plans for Spring Symposium 2019 at the University of Toledo


Final 2017-18 Project Presentations: University of Toledo part I

  1. Transporter table system

  2. Tapered reduction of cement volume in the proximal vertebrae adjacent to the fused segment may translate into a decreased rate of Proximal Junctional Kyphosis (PJK) using Calcium phosphate cement - A biomechanical investigation

  3. Development of hard antibacterial (TiN/Ag) coatings on orthopedic instruments fabricated from Ti-alloy

LUNCH in parallel with presentations

Final 2017-18 Project Presentations: University of Toledo part II

  1. Development of an innovative posterior pedicle-based screw device for multilevel semi-dynamic stabilization

  2. Effect of Talotarsal Joint Instability on Lower Extremity Alignment and the Role of Extra-osseous Talotarsal Joint Stabilization

  3. Biomechanical evaluation of the newly developed decompression surgery: Transforaminal ventral facetectomy


Closing Remarks

Dr. Jeffrey Lotz

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