Common treatments for sarcomas include surgery, radiation therapy, and chemotherapy. However, most of these treatments are highly invasive, non-responsive, and result in a significant collateral damage. The proposed effort will result in a minimally invasive procedure without the need of radiation therapy, and generate localized heat in situ. The magnetic compositions are achieved by doping injectable, self-setting calcium phosphate cement (CPC) compositions with iron. A monetite-based (Dicalcium phosphate anhydrous, DCPA) CPC composition will be used for this purpose. The microstructure, setting times, injectablility, biocompatibility, and bioactivity will be evaluated. Also, proof-of-concept for the self-set cement to generate localized temperature, which should be high enough to destroy tumors without causing collateral harm to local tissues will be provided.
Principal Investigator: Sarit Bhaduri, PhD
Trainee: Ethel Ruskin – Graduate student